"A 'Serpente' como senti minhas outras peças. É uma peça Nelson Rodrigues - A Serpente. Cargado Download as PDF or read online from Scribd. Flag for. Download as PDF or read online from Scribd . Nelson Rodrigues - A Serpente. Uploaded by. Paula Grati. Dario Fo - Morte acidental de um riapeocaconcou.ml O que e cinema - Jean-Claude riapeocaconcou.ml Nelson Rodrigues - A Serpente. O Cinema e a ProduÃ§Ã£o - Chris Rodrigues - PDF Free Download pdf.
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David George's book Nelson Rodrigues and the Invention of Brazilian such as Teatro do Pequeno Gesto's rendering of A serpente. Download PDF. PDF | riapeocaconcou.ml~latamst/riapeocaconcou.ml Nelson Rodrigues as Filmed by Arnaldo Jabor See "O cinema, segundo NelsonA serpente acariciada. Nelson Falcão Rodrigues (August 23, – December 21, ) was a Brazilian playwright, .. Toda Nudez Será Castigada; Anti-Nélson Rodrigues; A Serpente .. Create a book · Download as PDF · Printable version.
At her trial the woman admitted that her intention had been to kill Rodrigues' father Mario, the newspaper's owner; unable to find him, she settled for his son instead.
The ensuing years were dark ones for the Rodrigues family, and Nelson and his brothers were forced to seek work at rival newspapers for low wages. To make matters worse, in Nelson was diagnosed with tuberculosis, a disease that plagued him, on an off, for the next ten years.
During this time Rodrigues held various jobs including comic strip editor, sports columnists and opera critic. His following play, Vestido de Noiva The Wedding Dress , was hailed as a watershed in Brazilian theater and is considered among his masterpieces.
The stage is divided into three planes: one for real time action happening around the character, another for her memories, a third for her dying hallucinations. As the three planes overlap, reality melds with memory and delusion.
Slowly we discover the mystery of the woman's accident. Nelson Rodrigues, National Archives of Brazil. Nelson Rodrigues wrote 17 full-length plays, 9 novels and thousands of short stories.
From the beginning Rodrigues's plays shocked audiences and attracted the attention of censors. It was considered so controversial that it was censored and only allowed to be staged 21 years later. Other important earlier plays included "Anjo Negro" Black Angel , an explosive play held from the stage by censorship until that deals with issues of race and incest. In the play — which takes place in a semi-mythical setting, which is never identified  — a successful black doctor marries a white woman and their marriage cannot help but reflect the dysfunctional race relations of society at large.
The woman slowly kills their black children one by one, and the husband does nothing to intervene.
When the doctor's white brother arrives, his wife sleeps with him in the hopes of having a white son. In the play, a recently married man comforts a dying stranger who has just been run over in a traffic accident. A newspaper reporter witnesses the kiss and spins a salacious story that the two were lovers.
The kiss occurs before the play actually begins and, Rashomon-like, it assumes different characteristics according to who describes it. Slowly, the innuendos and lies begin to corrode the young man's marriage. The play was written in at the request of actress Fernanda Montenegro. Rodrigues reportedly wrote it in three weeks.
As the action unfolds, we become aware that nothing is as it seems. Four of the five daughters are prostitutes, and the one teen daughter who is held up as the symbol of chastity by the family is no longer a virgin. Amid an atmosphere where seemingly realist outlook becomes unreal vulgarity - the mother writes obscenities on the bathroom wall, the father prohibits the family from using toilet paper - the family's many unspoken secrets climax into a gruesome last scene.
It is a surreal play in which Rodrigues anticipates Ionesco and Beckett's theater of the absurd. The cousins disdain all sensuality and live a puritanical life of chastity and privations.
Various cellular roles of these proteins, including nuclear—cytoplasmic shuttling, pre-mRNA processing, hnRNP interactions, mRNP granule formation, and amyloid-like fibrillization, are diagrammed, with the domains implicated in these processes highlighted.
The vast majority of these mutations clusters in the C terminus of the protein, which is sometimes referred to as an hnRNP-interacting domain Ayala et al.
While the mutated amino acids are close to residues important for RNA binding Lukavsky et al. Some mutations are predicted to increase propensity for phosphorylation Kabashi et al.
These observations suggest that while changes in splicing and gene expression may be seen in disease, they are not due to differences in RNA recognition. These sequences are often enriched near TDPregulated exons Buratti et al.
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Furthermore, the finding that bound RNAs are enriched for multiple dispersed TDPbinding motifs suggests possible cooperative binding of multiple molecules to UG repeats that are spread out over nucleotide distances Tollervey et al. Loss of TDP function due to nuclear clearance can lead to particular splicing signatures of disease Polymenidou et al.
Intriguingly, it has been postulated that an important function of TDP is the repression of cryptic exons Fig.
While this result presents an important observable metric of TDP LOF in disease, such cryptic exons are not exclusively regulated by TDP and are bound by a number of other RBPs whose concentrations may vary in patients Humphrey et al. The patterns of cleavage that TDP undergoes are an interesting feature of disease. However, its contribution has been called into question due to the minor prevalence in the spinal cord Igaz et al. One proposed explanation for the toxicity of the C-terminal fragments Zhang et al.
Furthermore, the ability to bind RNA may underlie the organization of TDP oligomers, and loss of RNA-binding capability in truncated versions might promote aggregation Kitamura et al.
Once formed in the cytosol, these aggregates can then trap full-length TDP, disrupting its normal nucleo—cytoplasmic shuttling and leading to nuclear depletion Winton et al.
However, the existence of these fragments in the brains of patients with both mutant and wild-type TDP alike suggests that cleavage is not specifically driven by mutations Li et al.
The protein's ability to shuttle between the nucleus and cytoplasm might have important consequences for synaptic mRNA transport Fujii et al.
The lack of a consensus FUS-binding motif was echoed by CLIP experiments, which identified a predisposition for binding to stem—loop structures Hoell et al.
The brain is a site of increased transcriptional activity of genes with long introns, as expression of longer genes is overrepresented in neural tissue Gabel et al.
A cotranscriptional requirement of FUS and TDP for processing long introns may therefore underlie a critical function of these proteins that is specific to the brain Zylka et al. One such gene, MECP2, biologically interesting due to its relationship to the neuroregressive disease Rett syndrome, was found to be misspliced in cells transfected with mutant, but not wild-type, FUS Coady and Manley Such mutations have been proposed to influence the cytoplasmic aggregation and nuclear clearance of the protein.
One characteristic of FUS-ALS is that the gene harbors several mutations that lead to especially aggressive juvenile-onset forms of disease, such as the PL mutation Sharma et al.
An important question is whether these juvenile mutations affect the same functions and biochemical properties of FUS as mutations that lead to more classical ALS, such as RC, but to a more severe degree.
In a recently described mouse model, FUS lacking an NLS exhibited mislocalization to the cytoplasm that led to changes in gene expression and splicing that largely mirrored those caused by FUS ablation. However, mislocalization also led to up-regulation of genes involved in mRNA translation and to a subset of unique splicing changes that may reflect disruptions to other RBPs as a consequence of the cytoplasmic FUS aggregation Scekic-Zahirovic et al. It was also shown that both depletion and cytoplasmic mislocalization of FUS led to perinatal lethality due to respiratory insufficiency; however, mislocalization alone further resulted in perinatal MN death Scekic-Zahirovic et al.
In another mouse model, widespread postnatal elimination of FUS from the central nervous system as well as MN-specific elimination resulted in mice with normal postnatal survival without MN loss or denervation compared with control animals Sharma et al. RBPs and membraneless organelles While LOF contributions to pathogenesis cannot be ruled out, the expanding evidence for GOF has prompted more biochemically focused research into the structure and interactions of mutant and wild-type FUS.
This is due in part to the sequencing of large cohorts of patients and controls that has led to identification of presumed ALS-causing mutations in so-called intrinsically disordered regions IDRs Ticozzi et al.
Due to the rarity of these mutations, in-depth post-mortem analyses and identification of FUS pathology have been lacking. Additionally, the presence of these rare variants in sporadic patients makes the case for causality weaker than if they were seen as driving a recurrent phenotype in families. Despite these reasons to retain skepticism, mutations in the FUS prion-like and Gly-rich regions offer a new opportunity for unification with the rapidly expanding topic of liquid—liquid phase separation LLPS.
The idea that mutant versions of TDP and FUS lead to alterations of the biophysical properties of their IDRs has been gaining traction as part of a larger effort to characterize intracellular phase transitions undergone by membraneless organelles such as stress granules SGs and P bodies Brangwynne et al.
The formation of liquid droplets that partition as a separate phase from the surrounding medium are of interest because they are mediated by low-complexity domains LCDs , also known as IDRs. This predisposition to make self-interactions rather than solvent interactions has the potential to drive compaction and thus phase separation. Consequently, as concentrations of critical protein components rise, so does formation of these proteinaceous droplets, enabling spatial separation of important biochemical processes such as the partitioning of nucleic acids Nott et al.
These structures form in response to cellular stress as a means to temporarily halt translation of mRNAs not needed to respond to the situation at hand and thus can be viewed as temporary RNA storage sites. RNA transport granules are another important class of membrane-less organelles with specific neuronal relevance in localized mRNA expression Kiebler and Bassell Their ability to fuse into droplet states has become of great interest for disease because the properties driving this protective aggregation, which can involve phase transitions of mutant FUS and TDP, can also lead to amyloid-like states Fang et al.
This can be imagined as a transition from liquid droplets to hydrogels to irreversible amyloid fibers, giving rise to a gradient in rigidity Fig.
The ability of SGs to form rapidly and reversibly is an important aspect of their role in maintaining RNA homeostasis.
Despite the emphasis on the unstructured nature of IDRs, it has been proposed that transient, partially populated folded conformations, facilitated by particular amino acid stretches, may be disrupted by mutations, for instance, in TDP Conicella et al. TDP fibrilization is thought to seed aggregates of itself Furukawa et al. Such fibrillization by LCD-containing proteins is not necessary for phase separation and formation of granules but has been shown to increase in these conditions Molliex et al.
The ability to study the properties driving hydrogel formation and phase separation was augmented by the discovery that these molecules can be selectively precipitated using compounds such as biotinylated isoxazole Han et al.
However, the coexistence of RBDs and LCDs within the same proteins suggests that coalescence via association with the same RNAs serves to drive local concentrations to the point of phase transitions Molliex et al. While the precise nature of Matrin-3 in cellular granules with other disease-related proteins in unclear, such findings reinforce the convergence of different ALS genes in the same physical processes.His son, Serginho is the self-appointed guardian of his father's celibacy.
When the doctor's white brother arrives, his wife sleeps with him in the hopes of having a white son.
Rodrigues also wrote soap operas, movie scripts, and novels. Molecular phylogeny of the New World Dipsadidae Serpentes: These studies helped foster the view that disease is somehow triggered by injury, persistent stress, or activity-dependent demands from which cells with mutant TDP or FUS are slow or unable to recover Wolozin and Apicco The patterns of cleavage that TDP undergoes are an interesting feature of disease.
Second supralabial blackish. As a playwright, Rodrigues is frequently considered a realist , mostly on account of the self-acknowledged influence exerted on him by the dramatic work of Eugene O'Neill  - specially in his earlier, "mythical" plays.